Angiogenic Actions of Angiopoietin-1 Require Endothelium-Derived Nitric Oxide
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چکیده
منابع مشابه
The Possible Involvement of Nitric Oxide/Endothelium Derived Relaxing Factor in Atropine-Induced Vasorelaxation
Atropine has been used to block cholinergic neurotransmission in basic research. Large doses of atropine cause vasodilation of the blood vessels in the skin. This effect is apparently unconnected with the antimuscarinic activity of atropine and seems to be due to a direct action on the blood vessels. It has been suggested that atropine blocks muscarinic receptors at low doses and it induces th...
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About 10 years ago we discovered that bubbling nitric oxide (NO) gas into KrebsRinger bicarbonate solution containing isolated precontracted strips of bovine coronary artery caused a rapid and pronounced, but transient, relaxant response that was antagonized by oxidized hemoproteins, such as methemoglobin, and by methylene blue. NO activated soluble guanylate cyclase prepared from coronary arte...
متن کاملControl of regional blood flow by endothelium-derived nitric oxide.
The regional hemodynamic consequences of inhibiting vascular endothelial nitric oxide generation with NG-monomethyl-L-arginine (L-NMMA) were studied in conscious Long-Evans rats. Experiments were carried out in groups of chronically instrumented rats with intravascular catheters and pulsed Doppler probes to monitor regional blood flow. L-NMMA (0.3-300 mg/kg) caused a dose-dependent, long-lastin...
متن کاملPharmacological augmentation of endothelium-derived nitric oxide synthesis.
BACKGROUND The sympathetic nervous system has a unique role in endothelial function, and beta-receptors are a key part of sympathetic nervous system function. OBJECTIVE To elucidate the pharmacological augmentation of endotheliumderived nitric oxide synthesis. SUMMARY Beta-blockers have been commercially available since the 1960s. Stimulating beta-receptors causes dilatation whereas blockin...
متن کاملContribution of endothelium-derived nitric oxide to exercise-induced vasodilation.
BACKGROUND Endothelium-derived nitric oxide is an important modulator of resting vascular tone in animals and humans. However, the contribution of nitric oxide to exercise-induced vasodilation is unknown. METHODS AND RESULTS The effect of NG-monomethyl-L-arginine (L-NMMA), an inhibitor of nitric oxide synthesis, on exercise-induced vasodilation was studied in 18 healthy subjects (mean +/- SD,...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2003
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)64326-x